Gourab Bhattacharje

Assistant Professor

MIT School of Bioengineering Sciences & Research, MIT-ADT University, Pune

gourab.bhattacharje@mituniversity.edu.in

https://www.linkedin.com/in/gourab-bhattacharje-096612177/

Qualifications
  • 5-year integrated M.Sc. in Industrial Chemistry from IIT Kharagpur (2004-2009)
  • M.S. in Biology from the University of Utah, USA (2010-2014)
  • Ph D in Biotechnology, Indian Institute of Technology Kharagpur, India (2018-2024)
Experience
Teaching 1 year
Research 10 years
Career Highlights

Professional Experience

  • Lyozin GT, Kosaka Y, Bhattacharje G, Yost HJ, and Brunelli L. 2017. Direct isolation of seamless mutant bacterial artificial chromosomes. Curr. Protoc. Mol. Biol. 118:8.6.1‐8.6.29. doi://10.1002/cpmb.34
  • Dutta D, Rahman S*, Bhattacharje G*, et al. 2021. Label-Free Method Development for Hydroxyproline PTM Mapping in Human Plasma Proteome. Protein J. 40(5):741-755. doi://10.1007/s10930-021-09984-7
  • Rafi MO*, Bhattacharje G*, Al-Khafaji K, et al. 2022. Combination of QSAR, molecular docking, molecular dynamic simulation and MM-PBSA: analogues of lopinavir and favipiravir as potential drug candidates against COVID-19. J Biomol Struct Dyn. 40(8):3711-3730. doi://10.1080/07391102.2020.1850355
  • Shyam M, Verma H, Bhattacharje G, et al. 2022. Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition. J Med Chem. 65(1):234-256. doi://10.1021/acs.jmedchem.1c01349
  • Bhattacharje G, Ghosh A, Das AK. 2022. Understanding the Mannose Transfer Mechanism of Mycobacterial Phosphatidyl-myo-inositol Mannosyltransferase A from Molecular Dynamics Simulations, ACS Omega. 7(23):19288-19304. doi://10.1021/acsomega.2c00832
  • Chakraborty R*, Bhattacharje G*, Baral J*, Manna B*, et al. 2022. In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2. Comput. Biol. Med. 147 -105788. doi://10.1016/j.compbiomed.2022.105788
  • Singh R, Kundu P, Bhattacharje G, Das AK. 2022. Mycobacterium tuberculosis low molecular weight T-cell antigen Mtb8.4 has heme-binding and fiber-forming properties. FEBS Lett. 596 (20): 2678-2695. doi://10.1002/1873-3468.14446
  • Bhattacharje G, Ghosh A, Das AK. 2022. In-silico identification of critical residues in the mannose-transfer mechanism of phosphatidyl-myo-inositol mannosyltransferase B'. Biochem. Biophys. Res. Commun. 621: 14-19. doi://10.1016/j.bbrc.2022.06.087
  • Jana ID, Bhttacharya P, Mayilsamy K, Banerjee S, Bhattacharje G, et al. 2022. Targeting an evolutionarily conserved "E-L-L" motif in spike protein to identify a small molecule fusion inhibitor against SARS-CoV-2. PNAS Nexus., pgac198. doi://10.1093/pnasnexus/pgac198
  • Saha R, Bhattacharje G, Dey S, Das AK. 2023. Deciphering the conformational stability of MazE7 antitoxin in Mycobacterium tuberculosis from Molecular Dynamics simulation study. J Biomol Struct Dyn. doi://10.1080/07391102.2023.2280675
  • Bhattacharje G, Ghosh A, Das AK. 2023. Deciphering the mannose-transfer mechanism of mycobacterial PimE by molecular dynamics simulations. Glycobiol. doi://10.1093/glycob/cwad096
  • Shyam M, Bhattacharje G, Kumar A et al. 2023. Rationally designed novel phenyloxazoline synthase inhibitors: chemical synthesis and antimycobacterial evaluation to accelerate new antibiotic discovery against the TB-causing pathogens. Mol. doi://10.3390/molecules28248115
  • Bhattacharya P, Bhattacharje G, Hansda A, Das AK, Mukherjee G, Maiti MK. 2024. Unveiling the role of OsOle1: a major seed-specific oleosin isoform in rice for lipid accumulation and lipid droplet regulation. Plant Mol. Biol. Rep. doi://10.1007/s11105-024-01485-y
  • Baral J, Bhattacharje G, Dash S, Samanta D, Hinde E, Rouiller I, Das AK. 2024. In silico and in vitro characterization of the mycobacterial protein Ku to unravel its role in non-homologous end-joining DNA repair. Int. J. Biol. Macromol. doi://10.1016/j.ijbiomac.2024.134584

Conferences and Talks (Selected)

  • Bhattacharje G, Ghosh A, Das AK. In search of Models! Computational Models! (to counter drug resistance of Mycobacterium tuberculosis). Poster presented at the 2nd International Conference on Contemporary Antimicrobial Research 2018 at IIT Kharagpur, India.
  • Bhattacharje G, Ghosh A, Das AK. In-silico investigation of the mannose-transfer mechanism of Phosphatidyl-myo-inositol mannosyltransferases A and B. Poster presented at the EMBO Tuberculosis 2022 Conference hosted at Institut Pasteur, Paris, France.
  • Actively participated in the Technology Vision 2047 brainstorming workshop (1st - 2nd June, 2023) organized in IIT Kharagpur supported by TIFAC, DST, India.

International Recognitions

  • Reviewer of Computers in Biology and Medicine
  • Proofreading of Book and Manuscripts: 1. ISBN: 9781891389887/9781938787867
    2. doi://10.1039/C9RA09612D 3. doi://10.1038/s41598-019-52843-w

Fellowships, Memberships, And Other Extra-Curricular Activities

  • NET (2009-Chemistry), GATE (2018- Mathematics), National Talent Search Scholarship (2002)
  • Junior research fellowship from the biophysical sciences division, SINP, Kolkata, India (2009).
  • Best Project Award in the M.Sc. Dissertation topic in the batch of 5-year Integrated M.Sc. in Industrial Chemistry at IIT Kharagpur
  • Winner of Innovative Implementable Idea (I3) Award in SAMHAR-COVID19 HACKATHON organized by NVIDIA and C-DAC Pune, supported by MEIT and DST of Govt. of India (2020)
  • Winner of the “Creative Campus” idea contest organized by SPARK and Sports secretary of Indian Students Association (2012-13), University of Utah, Salt Lake City, UT
  • Hall President, General Secretary-Social and Cultural and Indoor Games Secretary of HJB Hall of Residence, IIT Kharagpur (2005-09), Sports Secretary, Indian Students Association, University of Utah (2011-12)
  • Winner of best actor award in Open IIT Bengali dramatics competition, IIT Kharagpur (2005)
  • Interested in Running, Chess, Dramatics, Taekwondo, Football, Pool, and Drawing portraits